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Intermittent Fasting & Longevity
Asked: Do a deep research report on intermittent fasting and longevity in humans with sources for every claim
Deep research report · evidence in humans
In humans, intermittent fasting reliably improves weight, body composition and cardiometabolic markers, and animal work links fasting to slower aging.
Bottom line
Time-restricted eating (e.g. eating within a daily window), alternate-day fasting, and periodic fasting such as the 5:2 pattern. The review literature groups these under 'intermittent and periodic fasting' [1].
What counts as intermittent fasting?
The umbrella review found IF may be comparable or modestly better than continuous calorie restriction for several outcomes in people with overweight or obesity [2][5]. It is not a magic switch.
Is it better than normal dieting?
Long, large randomized trials with mortality as the endpoint. Current trials focus on intermediate markers such as sleep, weight and metabolic health [12].
What would prove a longevity effect in humans?
If you take medication, are pregnant, have diabetes or a history of an eating disorder, talk to a clinician before starting a fasting protocol.
Not medical advice